Zylofuramine[1] is a stimulant drug. It was developed in 1961,[2][3] and was intended for use as an appetite suppressant and for the treatment of senile dementia in the elderly, but there is little information about it and it does not appear to have ever been marketed.[4]

Clinical data
ATC code
  • none
CAS Number
PubChem CID
Chemical and physical data
Molar mass219.328 g·mol−1
3D model (JSmol)

Its chemical structure has a similarity to other N-ethyl substituted stimulant drugs such as ethylamphetamine and N-Ethylhexedrone.


  1. US patent 3091621, Clarke, R. L., "Alpha-Aryl or Aralkyl Tetrahydrofurfurylamines", issued 1963-05-28, assigned to Sterling Drugs
  2. Clarke, R. L.; Harris, L. S. (1962). "α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. I". Journal of Medicinal Chemistry. 5 (1): 77–95. doi:10.1021/jm01236a010. PMID 14046619.
  3. Clarke, R. L.; Tullar, B. F.; Harris, L. S. (1962). "α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. II. Resolution of Isomers". Journal of Medicinal Chemistry. 5 (2): 362–372. doi:10.1021/jm01237a014. PMID 14051912.
  4. Harris, L. S.; Clarke, R. L.; Dembinski, J. R. (1963). "α-Benzyltetrahydrofurfurylamines -- A New Series of Psychomotor Stimulants. III. The Pharmacology of D-Threo α-Benzyl-N-Ethyltetrahydrofurfurylamine (Zylofuramine)". Archives Internationales de Pharmacodynamie et de Thérapie. 146: 392–405. PMID 14099588.

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