Bertram has guested in numerous television series and appeared in movies, as well as on stage. She is probably better known to international audiences for playing Randi Goodlove in Prisoner in 1983.
In 1991 she starred in the series Animal Park.
In 2009–2010 she appeared in a series of television advertisements for Australian Pensioners Insurance.
In July 2011, Bertram joined the cast of Neighbours as Lorraine Dowski. She re-joined the cast in the recurring role of Fay Brennan in 2017 and made her first onscreen appearance on 28 July.
- "Archived copy". Archived from the original on 27 September 2011. Retrieved 23 August 2011.CS1 maint: archived copy as title (link)
- Kilkelly, Daniel (25 July 2011). "'Neighbours' casts 'Prisoner' star Zoe Bertram". Digital Spy. Hachette Filipacchi UK. Retrieved 25 July 2011.
- Kilkelly, Daniel (17 July 2017). "Neighbours brings in Zoe Bertram as Mark, Aaron and Tyler's mum Fay Brennan". Digital Spy. Retrieved 17 July 2017.