Xylopropamine (Perhedrin, Esanin), also known as 3,4-dimethylamphetamine, is a stimulant drug of the phenethylamine and amphetamine classes which was developed and marketed as an appetite suppressant in the 1950s.
|Chemical and physical data|
|Molar mass||163.259 g/mol g·mol−1|
|3D model (JSmol)|
Xylopropamine was briefly sold as the sulfate salt, but it was not widely marketed. Other related amphetamine derivatives such as 2,4-dimethylamphetamine were also investigated for the same purpose, however these drugs had negative side effects such as high blood pressure and were not very successful, mainly due to the introduction of alternative drugs like phentermine which had similar efficacy but fewer side effects.
- US Patent 2384700
- HARRIS SC, WORLEY RC. Analgesic properties of xylopropamine. Proceedings of the Society for Experimental Biology and Medicine. 1957 Jun;95(2):212-5.
- RANDALL LO, SELITTO JJ, VALDES J. Anti-inflammatory effects of xylopropamine. Archives Internationales de Pharmacodynamie et de Thérapie 1957 Dec 1;113(1-2):233-49.
See also: Receptor/signaling modulators • Monoamine reuptake inhibitors • Adrenergics • Dopaminergics • Serotonergics • Monoamine metabolism modulators • Monoamine neurotoxins
(and close relatives)