Venomous fish

Venomous fish produce strong mixtures of toxins harmful to humans (called venom) which they deliver by means of a bite, sting, or stab. This results in an envenomation. As a contrast, poisonous fish also produce a strong toxin, but they do not bite, sting, or stab to deliver the toxin. Instead they are poisonous to eat because the human digestive system does not destroy the toxin they contain in their body.[1] Venomous fish don't necessarily cause poisoning if they are eaten, since the digestive system often destroys the venom.[1]

There are at least 1200 species of venomous fish.[2][3] This number accounts for two-thirds of the venomous vertebrate population.[4] There are more venomous fish than venomous snakes and indeed more than the combined total of all other venomous vertebrates.[2] Venomous fish are found in almost all habitats around the world, but mostly in tropical waters. They injure over 50,000 people every year.[5]

They carry their venom in venom glands and use various delivery systems, such as spines or sharp fins, barbs, spikes and fangs. The most common venom delivery system is via dorsal spines.[6] Venomous fish tend to be either very visible, using flamboyant colors to warn enemies, or skillfully camouflaged and maybe buried in the sand. Apart from the defense or hunting value, venom helps bottom dwelling fish by killing the bacteria that try to invade their skin. Few of these venoms have been studied. They are a yet to be tapped resource for bioprospecting to find drugs with medical uses.[3]


  • The most venomous known fish is the reef stonefish.[7][8] It has a remarkable ability to camouflage itself amongst rocks. It is an ambush predator that sits on the bottom waiting for prey to approach. Instead of swimming away if disturbed, it erects 13 venomous spines along its back. For defense it can shoot venom from each or all of these spines. Each spine is like a hypodermic needle, delivering the venom from two sacs attached to the spine. The stonefish has control over whether to shoot its venom, and does so when provoked or frightened.[3] The venom results in severe pain, paralysis and tissue death, and can be fatal if not treated. Despite its formidable defenses, stonefish have predators. Some bottom feeding rays and sharks with crushing teeth feed on them, as does the Stokes' seasnake.[9]
  • The lionfish is a venomous coral reef fish.[10] Unlike stonefish, a lionfish can release venom only if something strikes its spines. Although not native to the U.S. coast, lionfish have appeared around Florida and have spread up the coast to New York. They are attractive aquarium fish, sometimes used to stock ponds, and may have been washed into the sea during a hurricane. Lionfish can aggressively dart at scuba divers and attempt to puncture their facemask with their venomous spines.[3]
  • The stargazer buries itself and can deliver electric shocks as well as venom.[11] It is a delicacy in some cultures (cooking destroys the venom), and can be found for sale in some fish markets with the electric organ removed. They have been called "the meanest things in creation"[3]
  • Stingrays can sting and cause an injury with their stinger. Such envenomations can occur to people who wade in shallow water and tread on them. This can be avoided by shuffling through the sand or stamping on the bottom, as the rays detect this and swim away. The stinger usually breaks off in the wound. It is barbed, so it can easily penetrate but not so easily be removed. The stinger causes local trauma from the cut itself, pain and swelling from the venom, and possible later infection from bacteria. Occasionally severed arteries or death can result.[12]
  • Another very well-known venomous fish is the fang-tooth blenny. They have venom that contains the opioid-like enkephalin, phospholipase, and neuropeptide Y.[13] Enkephalin and phospholipase both produce inflammatory responses and neuropeptide Y induces a severe drop in blood pressure to the effected area.[14][15]. Blennies inject their venom via hollow, mandibular fangs.


Venomous fish are very often involved in human injury, usually by accident, but few studies have been done to investigate the constituents of fish venom. Even fewer studies have been done to create antivenom.

The only commercially available antivenom is for the Indo-Pacific stonefish, Synanceja trachynis Stonefish Antivenom (SFAV).[16]

Biological and Pharmacological Importance of Fish Venoms

It has been found that the mucous and sting venom of Potamotrygon cf. henlei, a species of stingray that is found in Brazil, is toxic to mice that have nociceptive, edematogenic, and proteolysis activities. Two peptides were isolated from the stingray venom, orpotrin, which causes vasoconstriction, and porflan, which causes inflammation. Knowing how these peptides are structured could lead to the development of a neutralization technique that could effectively act as an antivenom.[17]

Of all the piscine venoms studied, they all produce profound cardiovascular alterations, both in vivo and in vitro. These changes stimulate the release of nitric oxide from the endothelial cells, smooth muscle contractions, and other effects of the atria. Piscine venoms also produce neuromuscular activity effects- depolarization of nerve and muscle cells. In addition, piscine venoms have strong cytolytic activity. In experimental models and in Western immunoblotting analysis, all tested piscine venoms showed structural similarity, which could lead to the advent of an overarching antivenom or other novel uses. [18]

See also


  1. Poisonous vs. Venomous fish: What’s the difference? Reef Biosearch. Retrieved 17 July 2009.
  2. Smith WL and Wheeler WC (2006) "Venom Evolution Widespread in Fishes: A Phylogenetic Road Map for the Bioprospecting of Piscine Venoms" Journal of Heredity 97 (3):206-217.
  3. Grady, Denise Venom Runs Thick in Fish Families, Researchers Learn New York Times 22 August 2006.
  4. Sivan, Gisha (2009). "Fish venom: pharmacological features and biological significance". Fish and Fisheries. 10 (2): 159–172. doi:10.1111/j.1467-2979.2008.00309.x. ISSN 1467-2979.
  5. Venomous Fish Outnumber Snakes, LiveScience, 22 August 2006.
  6. Smith, W. Leo; Stern, Jennifer H.; Girard, Matthew G.; Davis, Matthew P. (2016-11-01). "Evolution of Venomous Cartilaginous and Ray-Finned Fishes". Integrative and Comparative Biology. 56 (5): 950–961. doi:10.1093/icb/icw070. ISSN 1540-7063.
  7. Froese, Rainer and Pauly, Daniel, eds. (2009). "Synanceja verrucosa" in FishBase. July 2009 version.
  8. "The Stonefish – The Deadliest Fish in The World", Virginia Wells,
  9. Reef Stonefish, Synanceia verrucosa (Bloch & Schneider, 1801) Australian Museum. Retrieved 21 July 2009.
  10. Froese, Rainer and Pauly, Daniel, eds. (2009). "Pterois volitans" in FishBase. July 2009 version.
  11. Froese, Rainer and Pauly, Daniel, eds. (2009). "Uranoscopus sulphureus" in FishBase. July 2009 version.
  12. Taylor, Geoff (March 2000). "Toxic fish spine injury: Lessons from 11 years experience" (pdf). Journal of the South Pacific Underwater Medicine Society. South Pacific Underwater Medicine Society. 30 (1): 7–8. ISSN 0813-1988. OCLC 16986801. Retrieved 10 June 2015.
  13. Losey GS. 1972. Predation protection in the poison-fang blenny, Meiacanthus atrodorsalis, and its mimics, Ecsenius bicolor and Runula laudandus (Blenniidae). Pac Sci 26(2): 129-139.
  14. Casewell, Nicholas. "The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes". Current Biology. 27: 1184–1191.
  15. Wilcox, Christie (March 30, 2017). [ "Beware the blenny's bite: scientists uncover the toxins in fang blenny venom"] Check |url= value (help). Discover.
  16. Gomes, Helena L.; Menezes, Thiago N.; Carnielli, Juliana B. T.; Andrich, Filipe; Evangelista, Karla S.; Chávez-Olórtegui, Carlos; Vassallo, Dalton V.; Figueiredo, Suely G. (2011-06-01). "Stonefish antivenom neutralises the inflammatory and cardiovascular effects induced by scorpionfish Scorpaena plumieri venom". Toxicon. 57 (7): 992–999. doi:10.1016/j.toxicon.2011.04.001. ISSN 0041-0101.
  17. Monteiro-dos-Santos, Juliane; Conceição, Katia; Seibert, Carla Simone; Marques, Elineide Eugênio; Ismael Silva, Pedro; Soares, Anderson Brito; Lima, Carla; Lopes-Ferreira, Mônica (2011-09-01). "Studies on pharmacological properties of mucus and sting venom of Potamotrygon cf. henlei". International Immunopharmacology. 11 (9): 1368–1377. doi:10.1016/j.intimp.2011.03.019. ISSN 1567-5769.
  18. Church, Jarrod E.; Hodgson, Wayne C. (2002-08-01). "The pharmacological activity of fish venoms". Toxicon. 40 (8): 1083–1093. doi:10.1016/S0041-0101(02)00126-5. ISSN 0041-0101.
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