Tolfenamic acid (Clotam) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland. Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.
|AHFS/Drugs.com||International Drug Names|
|CompTox Dashboard (EPA)|
|ECHA InfoCard||100.033.862 |
|Chemical and physical data|
|Molar mass||261.707 g/mol g·mol−1|
|3D model (JSmol)|
It is used in the UK as a treatment for migraine. It is generally not available in the US. It is available in some Asian, Latin American and European countries as a generic drug for humans and for animals.
- Andersen KV, Larsen S, Alhede B, Gelting N, Buchardt O (1989). "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities". J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447. doi:10.1039/P29890001443.
- Pentikäinen PJ, Neuvonen PJ, Backman C. "Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent". European Journal of Clinical Pharmacology. 19 (5): 359–65. doi:10.1007/bf00544587. PMID 7238564.
- NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
- NHS Tolfenamic Acid (Tolfenamic acid 200mg tablets) Page accessed July 3, 2015
- Drugs.com Drugs.com international listings for tolfenamic acid Page accessed July 3, 2015
- Tolfenamic acid information (Diseases Database)
|Pyrazolones / |
|Acetic acid derivatives|
and related substances
|Propionic acid derivatives|
See also: Receptor/signaling modulators • Transient receptor potential channel modulators