tert-Butyl bromide (also referred to as 2-Bromo-2-methylpropane) is an organic compound with a tert-butyl carbon frame and a bromine substituent. This organobromine compound is used as a raw material in synthetic organic chemistry. The compound is isomeric with 1-bromobutane and 2-bromobutane.
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||137.020 g·mol−1|
|Density||1.22 g mL−1 (at 20 °C)|
|Melting point||−16.20 °C; 2.84 °F; 256.95 K|
|Boiling point||73.3 °C; 163.8 °F; 346.4 K|
|310 nmol Pa−1 kg−1|
Refractive index (nD)
Heat capacity (C)
|165.7 J K mol−1|
Std enthalpy of
|−133.4 kJ mol−1|
|GHS Signal word||Danger|
|Flash point||16 °C (61 °F; 289 K)|
|Lethal dose or concentration (LD, LC):|
LD50 (median dose)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
2-Bromo-2-methylpropane was used to study the massive deadenylation of adenine based-nucleosides induced by halogenated alkanes (alkyl halides) under physiological conditions. 2-Bromo-2-methylpropane causes the massive deguanylation of guanine based-nucleosides and massive deadenylation of adenine based-nucleosides.
Phase transition from orthorhombic Pmn21 phase III at low temperatures (measurements from 95 K), to a disordered rhombohedral phase II at 205-213 K. Phase II can exist from 213-223 K, partly coincident with a FCC phase I, which can be observed between 210-250 K. Phase transitions have also been studied at high pressure (up to 300MPa)
- "2-Bromo-2-methylpropane - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 26 March 2005. Identification. Retrieved 16 June 2012.
- CRC Handbook of Chemistry and Physics 65th Ed.
- “2-Bromo-2-Methylpropane 135615.” H2NC6H4CO2C2H5, Drugs, www.sigmaaldrich.com/catalog/product/aldrich/135615?lang=en®ion=US.
- “2-Bromo-2-Methylpropane Structures.” The Cambridge Crystallographic Data Centre (CCDC), www.ccdc.cam.ac.uk/structures/search?id=doi:10.5517/ccvcqmj&sid=DataCite.