Technetium (99mTc) exametazime

Technetium (99mTc) exametazime is a radiopharmaceutical sold under the trade name Ceretec, and is used by nuclear medicine physicians for the detection of altered regional cerebral perfusion in stroke[1] and other cerebrovascular diseases. It can also be used for the labelling of leukocytes to localise intra-abdominal infections[2] and inflammatory bowel disease.[3] Exametazime (the part without technetium) is sometimes referred to by its chemical name of hexamethylpropyleneamine oxime or HMPAO.

Technetium (99mTc) exametazime
Clinical data
Trade namesCeretec
License data
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration
    Intravenous
    ATC code
    Legal status
    Legal status
    Identifiers
    CAS Number
    PubChem CID
    UNII
    Chemical and physical data
    FormulaC13H25N4O3Tc
    Molar mass383 g·mol−1
    3D model (JSmol)
    Chiralityracemic
     NY (what is this?)  (verify)

    Chemistry

    The drug consists of exametazime as a chelating agent for the radioisotope technetium-99m. Both enantiomeric forms of exametazime are used—the drug is racemic.[4] The third stereoisomer of this structure, the meso form, is not included.

    References

    1. Moretti, J. L.; Defer, G.; Cinotti, L.; Cesaro, P.; Degos, J. D.; Vigneron, N.; Ducassou, D.; Holman, B. L. (1990). ""Luxury perfusion" with 99mTc-HMPAO and 123I-IMP SPECT imaging during the subacute phase of stroke". European journal of nuclear medicine. 16 (1): 17–22. doi:10.1007/BF01566007. PMID 2307169.
    2. Weldon, M. J.; Joseph, A. E.; French, A.; Saverymuttu, S. H.; Maxwell, J. D. (1995). "Comparison of 99m technetium hexamethylpropylene-amine oxime labelled leucocyte with 111-indium tropolonate labelled granulocyte scanning and ultrasound in the diagnosis of intra-abdominal abscess". Gut. 37 (4): 557–564. doi:10.1136/gut.37.4.557. PMC 1382910. PMID 7489945.
    3. Ui, K.; Yamaguchi, T. (1991). "Therapy and diagnosis of emergency shock patients". Nihon Naika Gakkai zasshi. the Journal of the Japanese Society of Internal Medicine. 80 (12): 1892–1896. PMID 1804909.
    4. Monography in the European Pharmacopoeia
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