Table of medication secernated in kidney

This is a table of medications that are secreted in the kidney.

Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

Medication Location Acid or base [1] anion or cation[2] Percentage excreted[3]
para-aminohippurate proximal tubule[4]Acidanion
furosemide proximal tubule[4]Acidanion100-75
glucuronic acid-conjugates proximal tubule[4]Acid
glycine conjugates proximal tubule[4]Acid
indometacin proximal tubule[4]Acidanion
methotrexate proximal tubule[4]Acid100-75
penicillin proximal tubule[4]Acidanion75-50
(benzylpenicillin)
probenecid proximal tubule[4]Acidanion
sulphate conjugates proximal tubule[4]Acid
thiazide diuretics proximal tubule[4]Acid
uric acid proximal tubule[4]Acid
amiloride proximal tubule[4]Basecation
dopamine proximal tubule[4]Base
histamine proximal tubule[4]Base
mepacrine proximal tubule[4]Base
morphine proximal tubule[4]Basecation
pethidine proximal tubule[4]Base
quaternary ammonium compounds proximal tubule[4]Base
quinine proximal tubule[4]Basecation
5-hydroxytryptamine (serotonin) proximal tubule[4]Base
triamterene proximal tubule[4]Base
gentamicin 100-75
atenolol 100-75
digoxin 100-75
cimetidine cation75-50
tetracycline 75-50
(oxytetracycline)
neostigmine 75-50
propantheline ~50
tubocurarine ~50
acetazolamide proximal tubule[5]anion
chlorothiazide proximal tubule[5]anion
saccharin proximal tubule[5]anion
salicylate proximal tubule[5]anion
atropine proximal tubule[5]cation
NMN proximal tubule[5]cation
paraquat proximal tubule[5]cation
procainamide proximal tubule[5]cation
tetraethylammonium proximal tubule[5]cation
chlorpromazine proximal tubule[5]cation

References

  1. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
  2. Unless else specified in table boxes, then ref is Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
  3. Unless else specified in table boxes, then ref is Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 113
  4. Rang, H. P. (2003). Pharmacology. Edinburgh: Churchill Livingstone. ISBN 0-443-07145-4. Page 112
  5. Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 802
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