Sodium orthovanadate

Sodium orthovanadate is the inorganic compound with the chemical formula Na3VO4·2H2O (sodium orthovanadate dihydrate). It is a salt of the VO3−
oxyanion. It is a colorless, water-soluble solid.[2]

Sodium orthovanadate
IUPAC name
Sodium vanadate(V)
Other names
Sodium vanadium oxide
3D model (JSmol)
ECHA InfoCard 100.033.883
RTECS number
  • YW1120000
Molar mass 183.908 g/mol
Appearance white powder
Density 2.16 g/cm3, solid
Melting point 858 °C (1,576 °F; 1,131 K)
22.17 g/100 mL
Solubility insoluble in ethanol
164.8 J/mol K
190 J/mol K
−1757 kJ/mol
Main hazards Harmful.
NFPA 704 (fire diamond)
Flash point Non-flammable
Lethal dose or concentration (LD, LC):
330 mg/kg (oral, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

Synthesis and structure

Sodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide:

V2O5 + 6 NaOH → 2 Na3VO4 + 3 H2O

The salt features tetrahedral VO3−
centers linked to octahedral Na+ sites.[3]


Acidification of orthovanadate induces condensation to polyoxovanadates, specifically decavanadate.[4]

Vanadates exhibit a variety of biological activities, in part because they serve as structural mimics of phosphates.[5][6] It acts as a competitive inhibitor of ATPases, alkaline and acid phosphatases, and protein-phosphotyrosine phosphatases,[7] and its inhibitory effects can be reversed by dilution or the addition of Ethylenediaminetetraacetic acid (EDTA).[8]

Orthovanadate is activated by boiling and adjusting pH to ~10; this depolymerizes decavanadate into the active inhibitor, monovanadate.[7]


  2. Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. ISBN 978-0-08-037941-8.
  3. Kato, K.; Takayama-Muromachi, E. (1987). "Die Struktur des Trinatriumvanadattrihydrats" [The structure of trisodium vanadate trihydrate] (PDF). Acta Crystallogr. C43: 1030–1032. doi:10.1107/S0108270187093120.
  4. Klemperer, W. G.; Yaghi, O. (1983). "Tetrabutylammonium Trihydrogen Decavanadate(V)". Inorg. Synth. 27: 83. doi:10.1002/9780470132586.ch15.
  5. Korbecki, Jan; Baranowska-Bosiacka, Irena; Gutowska, Izabela; Chlubek, Dariusz (2012). "Biochemical and medical importance of vanadium compounds" (PDF). Acta Biochim. Polon. 59: 195–200.
  6. Crans, D. C.; Chatterjee, P. B. (2013). "Vanadium biochemistry". In Reedijk, Jan; Poeppelmeier, Kenneth (eds.). Comprehensive Inorganic Chemistry II. 3. pp. 323–342. doi:10.1016/B978-0-08-097774-4.00324-7. ISBN 978-0-08-097774-4.
  7. "Sodium orthovanadate" (PDF). Sigma-Aldrich. Retrieved September 7, 2018.
  8. Biolabs, New England. "Sodium Orthovanadate (Vanadate) | NEB". Retrieved 2018-09-07.

See also

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