Sodium cyclamate (sweetener code 952) is an artificial sweetener. It is 30–50 times sweeter than sucrose (table sugar), making it the least potent of the commercially used artificial sweeteners. It is often used with other artificial sweeteners, especially saccharin; the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. It is less expensive than most sweeteners, including sucralose, and is stable under heating. Safety concerns have led to cyclamates being banned in the United States and other countries, though the European Union recognizes them as safe.
3D model (JSmol)
|E number||E952(iv) (glazing agents, ...)|
CompTox Dashboard (EPA)
|Molar mass||201.22 g·mol−1|
|NFPA 704 (fire diamond)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by the sulfonation of cyclohexylamine. This can be accomplished by reacting cyclohexylamine with either sulfamic acid or sulfur trioxide.
Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in kerosene) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage.
Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. Sveda was working in the lab on the synthesis of anti-fever medication. He put his cigarette down on the lab bench, and, when he put it back in his mouth, he discovered the sweet taste of cyclamate.
The patent for cyclamate was purchased by DuPont but later sold to Abbott Laboratories, which undertook the necessary studies and submitted a New Drug Application in 1950. Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital. In 1958, it was designated GRAS (Generally Recognized as Safe) by the United States Food and Drug Administration. Cyclamate was marketed in tablet form for use by diabetics as an alternative tabletop sweetener, as well as in a liquid form. As cyclamate is stable to heat, it was and is marketed as suitable for use in cooking and baking.
In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce cyclohexylamine, a compound suspected to have some chronic toxicity in animals. Further research resulted in a 1969 study that found the common 10:1 cyclamate–saccharin mixture increased the incidence of bladder cancer in rats. The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels equivalent to humans ingesting 550 cans of diet soda per day, developed bladder tumors.
Sales continued to expand, and in 1969, annual sales of cyclamate had reached $1 billion, which increased pressure from public safety watchdogs to restrict the usage of cyclamate. In October 1969, Department of Health, Education & Welfare Secretary Robert Finch, bypassing Food and Drug Administration Commissioner Herbert L. Ley, Jr., removed the GRAS designation from cyclamate and banned its use in general-purpose foods, though it remained available for restricted use in dietary products with additional labeling; in October 1970, the FDA, under a new commissioner, banned cyclamate completely from all food and drug products in the United States.
Abbott Laboratories claimed that its own studies were unable to reproduce the 1969 study's results, and, in 1973, Abbott petitioned the FDA to lift the ban on cyclamate. This petition was eventually denied in 1980 by FDA Commissioner Jere Goyan. Abbott Labs, together with the Calorie Control Council (a political lobby representing the diet foods industry), filed a second petition in 1982. Although the FDA has stated that a review of all available evidence does not implicate cyclamate as a carcinogen in mice or rats, cyclamate remains banned from food products in the United States. The petition is now held in abeyance, though not actively considered. It is unclear whether this is at the request of Abbott Labs or because the petition is considered to be insufficient by the FDA.
In 2000, a paper was published describing the results of a 24-year-long experiment in which 16 monkeys were fed a normal diet and 21 monkeys were fed either 100 or 500 mg/kg cyclamate per day; the higher dose corresponds to about 30 cans of a diet beverage. Two of the high-dosed monkeys and one of the lower-dosed monkeys were found to have malignant cancer, each with a different kind of cancer, and three benign tumors were found. The authors concluded that the study failed to demonstrate that cyclamate was carcinogenic because the cancers were all different and there was no way to link cyclamate to each of them. The substance did not show any DNA-damaging properties in DNA repair assays.
- Assugrin (Switzerland, Brazil)
- Cap Cangkir (Indonesia)
- Chuker (Argentina) - Merisant Company 2, SARL
- Huxol (Germany) in liquid form
- Novasweet (Russia)
- Rio (Produced under license and authority of SweetLife AG Switzerland by SweetLife Ltd, China)
- Sugar Twin (Canada)
- Suitli (Bulgaria)
- Sweet'n Low (Canada)
Notes and references
- Jim Smith, Lily Hong-Shum (April 15, 2008). Food Additives Data Book. John Wiley & Sons. p. 960. ISBN 9781405172417.
- McKetta Jr, John J. (June 19, 1996). "Sweeteners, High Intensity". Encyclopedia of Chemical Processing and Design. 56: 72. ISBN 9780824726072.
- Packard, Vernal S. (1976). Processed foods and the consumer: additives, labeling, standards, and nutrition. Minneapolis: University of Minnesota Press. pp. 332. ISBN 0-8166-0778-8.
- Kaufman, Leslie (August 21, 1999). "Michael Sveda, the Inventor Of Cyclamates, Dies at 87". New York Times.
- Taubes, Gary (2017). The Case against Sugar. London, England: Portobello books. pp. 143–144. ISBN 9781846276378.
- Chedd, Grahm (May 9, 1974). "The Search for Sweetness". New Scientist. 62 (897): 299.
- Goyan, Jere E., Commissioner of Food and Drugs. (September 4, 1980). "Cyclamate, Commissioner's Decision, 45 FR 61474" (PDF). Office of the Federal Register. pp. 61474–61530. Retrieved February 8, 2015.
[...] approval of cyclamate for use as a sweetening agent in food and for technological purposes in food is denied.CS1 maint: multiple names: authors list (link)
- "FDA Talk Paper, NAS Report on Cyclamate" (PDF).
- "Petitions Currently Held in Abeyance". Retrieved February 8, 2015.
FAP 2A3672 Cyclamate (cyclamic acid, calcium cyclamate, and sodium cyclamate)
- Weihrauch MR, Diehl V (2004). "Artificial sweeteners—do they bear a carcinogenic risk?". Ann Oncol. 15 (10): 1460–5. doi:10.1093/annonc/mdh256. PMID 15367404.
- "Worldwide Status of Cyclamate" (PDF). Calorie Control Council. Retrieved November 23, 2018.
- Ashurst, Philip R. (April 15, 2008). Chemistry and Technology of Soft Drinks and Fruit Juices. John Wiley & Sons. p. 247.
- "FDA lifts ban on 'magic sugar' - Philstar.com". philstar.com.
"High-Intensity Sweeteners". U.S. Food and Drug Administration. May 19, 2014. Retrieved February 8, 2015.
Are there any high-intensity sweeteners that are currently prohibited by FDA for use in the United States but are used in other countries? Yes. Cyclamates and its salts (such as calcium cyclamate, sodium cyclamate, magnesium cyclamate, and potassium cyclamate) are currently prohibited from use in the United States.
- "Everything Added to Food in the United States (EAFUS), Search Criteria = "cyclamate"". U.S. Food and Drug Administration. Retrieved February 8, 2015.
- Newton, David E (January 1, 2009). Food Chemistry. pp. 73–77. ISBN 9781438109756.
- 사이클라민산나트륨 (in Korean). Retrieved August 23, 2018.
- "Tastes like sugar". Retrieved November 1, 2010.
- Assugrin's website (in French)
- "Новапродукт". novaprodukt.ru.
- "SugarTwin - Artificial Sweeteners - Brown Sugar Substitutes - Calorie Free". Sugar Twin.
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