Rnd3

Rnd3 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[5] It is encoded by the gene RND3.[6]

RND3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRND3, ARHE, Rho8, RhoE, memB, Rnd3, Rho family GTPase 3
External IDsOMIM: 602924 MGI: 1921444 HomoloGene: 21074 GeneCards: RND3
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q23.3Start150,468,195 bp[1]
End150,539,011 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

390

74194

Ensembl

ENSG00000115963

ENSMUSG00000017144

UniProt

P61587

P61588

RefSeq (mRNA)

NM_005168
NM_001254738

NM_028810

RefSeq (protein)

NP_001241667
NP_005159

NP_083086

Location (UCSC)Chr 2: 150.47 – 150.54 MbChr 2: 51.13 – 51.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Like other members of the Rho family of Ras-related GTPases it regulates the organization of the actin cytoskeleton in response to extracellular growth factors.

Regulation

Like Ras, Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al., 1998).[supplied by OMIM][6]


Interactions

Rnd3 has been shown to interact with ARHGAP5[7] and UBXD5.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000115963 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017144 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
  6. "Entrez Gene: RND3 Rho family GTPase 3".
  7. Wennerberg, Krister; Forget Marie-Annick; Ellerbroek Shawn M; Arthur William T; Burridge Keith; Settleman Jeffrey; Der Channing J; Hansen Steen H (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106–15. doi:10.1016/S0960-9822(03)00418-4. ISSN 0960-9822. PMID 12842009.
  8. Katoh, Hironori; Harada Amane; Mori Kazutoshi; Negishi Manabu (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/MCB.22.9.2952-2964.2002. ISSN 0270-7306. PMC 133765. PMID 11940653.

Further reading


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