Rnd2

Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases.[5] It is encoded by the gene RND2.[6]

RND2
Identifiers
AliasesRND2, ARHN, RHO7, RhoN, Rnd2, Rho family GTPase 2
External IDsOMIM: 601555 MGI: 1338755 HomoloGene: 21123 GeneCards: RND2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.31Start43,025,231 bp[1]
End43,032,041 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8153

11858

Ensembl

ENSG00000108830

ENSMUSG00000001313

UniProt

P52198

Q9QYM5

RefSeq (mRNA)

NM_005440

NM_009708

RefSeq (protein)

NP_005431

NP_033838

Location (UCSC)Chr 17: 43.03 – 43.03 MbChr 11: 101.46 – 101.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][7]

This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.

Clinical significance

The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.[6]

Interactions

Rnd2 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000108830 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000001313 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ridley AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. ISSN 0962-8924. PMID 16949823.
  6. "Entrez Gene: RND2 Rho family GTPase 2".
  7. "Entrez Gene: RND1 Rho family GTPase 1".
  8. Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003). "Rnd proteins function as RhoA antagonists by activating p190 RhoGAP". Curr. Biol. 13 (13): 1106–15. doi:10.1016/s0960-9822(03)00418-4. PMID 12842009.
  9. Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G (May 2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". Biochem. J. 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. PMC 1223378. PMID 12590651.
  10. Katoh H, Harada A, Mori K, Negishi M (May 2002). "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers". Mol. Cell. Biol. 22 (9): 2952–64. doi:10.1128/mcb.22.9.2952-2964.2002. PMC 133765. PMID 11940653.

Further reading


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