Rif (GTPase)

Rif is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases.[1] It is primarily active in the brain and plays a physiological role in the formation of neuronal dendritic spine. This process is regulated by FARP1, a type of activator for RhoA GTPases.[2] Alternatively, Rif can induce the formation of actin stress fibers in epithelial cells. Which is dependent on the activity levels of ROCK proteins since the absence of ROCK activity would mean Rif would be unable to stimulate the growth of stress fibers.[3]


  1. Ridley, Anne J. (October 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–529. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
  2. Fan, Lifei; Yan, Huijuan; Pellegrin, Stephanie; Morigen; Mellor, Harry (March 2015). "The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction". Neuroscience Letters. 590: 178–183. doi:10.1016/j.neulet.2015.02.010. PMID 25668492.
  3. Fan, Lifei; Pellegrin, Stephanie; Scott, Alice; Mellor, Harry (April 15, 2010). "The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells" (PDF). Journal of Cell Science. 123 (Pt 8): 1247–1252. doi:10.1242/jcs.061754. PMC 2848113. PMID 20233848.

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