Rac (GTPase)

Rac is a subfamily of the Rho family of GTPases,[1] small (~21 kDa) signaling G proteins (more specifically a GTPase). When bound to GTP, Rac is activated. In its activated state, Rac participates in the regulation of cell movement, through its involvement in structural changes to the actin Cytoskeleton.[2]

The subgroup include:

Some research has suggested that Rac could be involved in mediating the process of forgetting.[3][4]


  1. Ridley A. (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
  2. "Rac", Encyclopedia of Cancer, Springer Berlin Heidelberg, 2011, p. 3133, doi:10.1007/978-3-642-16483-5_4891, ISBN 9783642164828
  3. Shuai, Yichun; Lu, Binyan; Hu, Ying; Wang, Lianzhang; Sun, Kan; Zhong, Yi (2010-02-19). "Forgetting Is Regulated through Rac Activity in Drosophila". Cell. 140 (4): 579–589. doi:10.1016/j.cell.2009.12.044. PMID 20178749.
  4. http://scitechstory.com/2010/02/19/brain-memory-is-actively-cleared/

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.