Protein-synthesizing GTPase

Protein-synthesizing GTPases (EC, elongation factor (EF), initiation factor (IF), peptide-release or termination factor) are enzymes involved in mRNA translation into protein by the ribosome, with systematic name GTP phosphohydrolase (mRNA-translation-assisting).[1][2][3][4][5] They usually include translation initiation factors such as IF-2 and translation elongation factors such as EF-Tu.

Protein-synthesizing GTPase
EC number3.6.5.3
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum


  1. Kurzchalia TV, Bommer UA, Babkina GT, Karpova GG (October 1984). "GTP interacts with the gamma-subunit of eukaryotic initiation factor eIF-2". FEBS Letters. 175 (2): 313–6. doi:10.1016/0014-5793(84)80758-9. PMID 6566615.
  2. Kisselev LL (1995). "Termination of translation in eukaryotes". Biochemistry and Cell Biology. 73 (11–12): 1079–86. doi:10.1139/o95-116. PMID 8722024.
  3. Rodnina MV, Savelsbergh A, Katunin VI, Wintermeyer W (January 1997). "Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome". Nature. 385 (6611): 37–41. doi:10.1038/385037a0. PMID 8985244.
  4. Freistroffer DV, Pavlov MY, MacDougall J, Buckingham RH, Ehrenberg M (July 1997). "Release factor RF3 in E.coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner". The EMBO Journal. 16 (13): 4126–33. doi:10.1093/emboj/16.13.4126. PMC 1170035. PMID 9233821.
  5. Krab IM, Parmeggiani A (November 1998). "EF-Tu, a GTPase odyssey". Biochimica et Biophysica Acta. 1443 (1–2): 1–22. doi:10.1016/s0167-4781(98)00169-9. PMID 9838020.

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