Perafensine (INN) (code name HR-459) is a drug which was investigated as an antidepressant but was never marketed.[1] It has been reported to antagonize the effects of reserpine and to inhibit the reuptake of norepinephrine (norepinephrine reuptake inhibitor); whether it also affects the reuptake of serotonin or dopamine is unclear.[2]

Clinical data
ATC code
  • None
Legal status
Legal status
  • Abandoned
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass289.374 g/mol g·mol−1
3D model (JSmol)

See also


  1. C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1585–. ISBN 978-0-412-46630-4.
  2. Bondinell, WilliamE.; Kaiser, Carl (1982). "Chapter 5. Antidepressants". 17: 41–50. doi:10.1016/S0065-7743(08)60487-X. ISSN 0065-7743. Cite journal requires |journal= (help)
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