Oral administration is a route of administration where a substance is taken through the mouth. Per os (P.O.) is sometimes used as an abbreviation for medication to be taken orally. Many medications are taken orally because they are intended to have a systemic effect, reaching different parts of the body via the bloodstream, for example.
Oral administration of a tablet
|Other names||By mouth, per os (PO)|
Per os (//; P.O.) is an adverbial phrase meaning literally from Latin "by opening" or "by way of the opening." The expression is used in medicine to describe a treatment that is taken orally. The abbreviated P.O. is often used on medical prescriptions. P.O. is also occasionally rendered per orem, which is sometimes corrupted to per oram. These are grammatically incorrect; "os" is a neuter noun of the 3rd declension and thus the accusative case is the same as the nominative case.
Oral administration is a part of internal administration, which also includes
- Buccal, dissolved inside the cheek
- Sublabial, dissolved under the lip
- Sublingual administration, dissolved under the tongue, but due to rapid absorption many consider SL a parenteral route
- Tablets to swallow, chew or dissolve in water or under the tongue
- Capsules and chewable capsules (with a coating that dissolves in the stomach or bowel to release the medication there)
- Time-release or sustained-release tablets and capsules (which release the medication gradually)
- Powders or granules
- Liquid medications or syrups
Concomitant ingestion of water facilitates in swallowing tablets and capsules. If the substance has disagreeable taste, addition of a flavor may facilitate ingestion. Substances that are harmful to the teeth are preferably given through a straw.
- Institute for Quality and Efficiency in Health Care. "Oral medications". Informed Health Online. Institute for Quality and Efficiency in Health Care. Retrieved 22 June 2013.
- TheFreeDictionary > oral administration of medication Citing: Mosby's Medical Dictionary, 8th edition. 2009