The roadway begins at Wellington Street, at Parliament Hill, proceeding south towards the Queensway (Highway 417) where there is a westbound on-ramp. South of the Queensway, O'Connor continues as a local street in The Glebe neighbourhood until it reaches its southern terminus at Holmwood Avenue.
A two-way cycle track was built along the street in 2016.
(from North to South):
- Ottawa Transportation Master Plan, see map 7 Central Area/Inner City Road Network