Mandelin reagent

The Mandelin reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of ammonium metavanadate and concentrated sulfuric acid. Its primary use is for the detection of ketamine and PMA[1] It is unusual among reagent tests that it has a very strong yellow colour prior to being used for testing, which forms within about 48 hours of mixing.[2]

The United States Department of Justice method for producing the reagent is the addition of 100 mL of concentrated (95–98%) sulfuric acid to 0.5[3]-1 g of Ammonium metavanadate.[4]

This reagent was invented by the German pharmacologist, Karl Friedrich Mandelin (18541906) at the University of Dorpat.

Final colors produced by Mandelin Reagent with various substances[4]
Substance Color
2C-T-7Maroon to Black[5]
AcetaminophenModerate olive
BenzphetamineBrilliant yellow green
ChlorpromazineDark olive
CocaineDeep orange yellow
CodeineDark olive
d-AmphetamineModerate bluish green
d-MethamphetamineDark yellowish green
Diacetylmorphine (Heroin)Moderate reddish brown
Dimethoxy-methDark olive brown
DoxepinVery reddish brown
DristanGreyish olive
ExedrineDark olive
KetamineDeep reddish orange[1]
MaceModerate olive green
MDABluish black[6]
MDMABluish black[6]
MescalineDark yellowish brown
MethadoneDark greyish blue
MethaqualoneVery orange yellow
MethylphenidateBrilliant orange yellow
Morphine monohydrateDark greyish reddish brown
OpiumOlive black
OxycodoneDark greenish yellow
ProcaineDeep orange
PropoxypheneDark reddish brown
PsilocybinGreen [7]
Paramethoxyamphetamine (PMA)Reddish brown [1]
Paramethoxymethamphetamine (PMMA)Reddish brown [1]
Salt (NaCl)Strong orange

See also


  1. "Mandelin EZ Testing Kit". EZ Test. Retrieved 2012-01-27.
  2. "Reagent Tests UK - Mandelin reagent". Reagent Tests UK. Retrieved 3 April 2016.
  3. Poe, Charles F.; O'Day, David W. (2006). "A study of Mandelin's test for strychnine". Journal of the American Pharmaceutical Association. 19 (12): 1292. doi:10.1002/jps.3080191206.
  4. "Color Test Reagents/Kits for Preliminary Identification of Drugs of Abuse" (PDF). Law Enforcement and Corrections Standards and Testing Program. July 2000. Retrieved 2011-07-24.
  5. "2-C-T-7 Mandelin". Reagent Base.
  6. "Dancesafe Mandelin Reagent". Dancesafe. Retrieved 10 August 2015.
  7. Mahmood, Zafar Alam (2013). "Bioactive Alkaloids from Fungi: Psilocybin". Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes. Springer-Verlag. pp. 523–552. ISBN 978-3-642-22143-9.

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