MPPF, with the full name 2'-methoxyphenyl-(N-2'-pyridinyl)-p-fluoro-benzamidoethyipiperazine, is a compound that binds to the serotonin-1A receptor. Labeled with fluorine-18 it has been used as a radioligand with positron emission tomography. It has, e.g., been used to examine the difference in neuroreceptor binding in the human brain across sex and age.
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||434.51 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
- D. Le Bars (May 1998). "High-Yield Radiosynthesis and Preliminary In Vivo Evaluation of p-18FMPPF, a Fluoro Analog of WAY-100635". Nuclear Medicine and Biology. 25 (4): 343–350. doi:10.1016/S0969-8051(97)00229-1.
- Nicolas Costes; Merlet, I; Ostrowsky, K; Faillenot, I; Lavenne, F; Zimmer, L; Ryvlin, P; Le Bars, D (December 2005). "A18F-MPPF PET normative database of 5-HT1A receptor binding in men and women over aging". the Journal of Nuclear Medicine. 46 (12): 1980–1989. PMID 16330560.