MK-212 (CPP or 6-chloro-2-(l-piperazinyl)pyrazine)[1] is a serotonin agonist.[2] It promotes the secretion of serum prolactin and cortisol in humans.[3]

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3D model (JSmol)
Molar mass 198.65 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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In an experiment performed by Clineschidt and colleagues, they dosed mice with varying concentrations of MK-212, and observed its effects.[4] The result correlated very well to binding of indolealkylamine receptors, such as the serotonin and tryptamine receptors, which shows four characteristics. Namely, increased frequency of muscle twitching, increased twitching of the head, "an increase in the strength of the crossed extensor reflex in the acutely spinalized rat", and the cause of complex motor syndrome.[4]


  1. Clineschidmt, BV (1979). "MK-212: A serotonin-like agonist in the CNS". General pharmacology. 10 (4): 287–90. PMID 488663.
  2. Bastani, B.; Nash, J. F.; Meltzer, H. Y. (1990). "Prolactin and Cortisol Responses to MK-212, a Serotonin Agonist, in Obsessive-Compulsive Disorder". Archives of General Psychiatry. 47 (9): 833–9. doi:10.1001/archpsyc.1990.01810210041006. PMID 2203327.
  3. Lowy, Martin T.; Meltzer, Herbert Y. (1988). "Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist". Biological Psychiatry. 23 (8): 818–28. doi:10.1016/0006-3223(88)90070-4. PMID 3365458.
  4. Clineschmidt, Bradley V.; McGuffin, Jodie C.; Pflueger, A.Barbara (1977). "Central serotonin-like activity of 6-chloro-2-[1-piperazinyl]-pyrazine (CPP; MK-212)". European Journal of Pharmacology. 44 (1): 65–74. doi:10.1016/0014-2999(77)90117-0. ISSN 0014-2999.
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