Laboratory animal allergy
Laboratory animal allergy (LAA) is an occupational disease of laboratory animal technicians and scientists. It manifests as an allergic response to animal urine, specifically the major urinary proteins (Mups) of rodents, and can lead to the development of asthma. A study of 5641 workers in Japan who were exposed to laboratory animals found 23.1% had one or more allergic symptoms; globally the prevalence among at risk workers is estimated between 11 and 30% According to the National Institutes of Health, prevention of animal allergy depends on the control of allergens in the work environment. This involves a combination of measures to eliminate or control allergen exposure, including engineering controls, administrative controls, and personal protective equipment.
The protein product of the mouse Mup17 gene, known as Mus m 1, Ag1 or MA1, accounts for much of the allergenic properties of mouse urine. Similarly, the product of the rat Mup13 gene, Rat n 1, is also a potent human allergen. One study found that two thirds of laboratory workers who had developed asthmatic reactions to animals had antibodies to Rat n 1.
- Gordon S, Preece R (September 2003). "Prevention of laboratory animal allergy". Occupational Medicine. 53 (6): 371–7. doi:10.1093/occmed/kqg117. PMID 14514903.
- Wood RA (2001). "Laboratory animal allergens". ILAR Journal. 42 (1): 12–6. doi:10.1093/ilar.42.1.12. PMID 11123185.
- Lockey, Richard; Ledford, Dennis K. (2008). "Mammalian Allergens". Allergens and Allergen Immunotherapy. Volume 21 of Clinical allergy and immunology. Informa Health Care. pp. 201–218. ISBN 978-1-4200-6197-0.
- Aoyama K, Ueda A, Manda F, Matsushita T, Ueda T, Yamauchi C (January 1992). "Allergy to laboratory animals: an epidemiological study". British Journal of Industrial Medicine. 49 (1): 41–7. doi:10.1136/oem.49.1.41. PMC 1039233. PMID 1733454.
- The National Institutes of Health Laboratory Animal Allergy Prevention Program
- Garg LC, Narang N (1989). "Suppression of ouabain-insensitive K-ATPase activity in rabbit nephron segments during chronic hyperkalemia". Renal Physiology and Biochemistry. 12 (5–6): 295–301. doi:10.1159/000173206. PMID 2533699.
- Lorusso JR, Moffat S, Ohman JL (November 1986). "Immunologic and biochemical properties of the major mouse urinary allergen (Mus m 1)". The Journal of Allergy and Clinical Immunology. 78 (5 Pt 1): 928–37. doi:10.1016/0091-6749(86)90242-3. PMID 3097107.
- Platts-Mills TA, Longbottom J, Edwards J, Cockroft A, Wilkins S (March 1987). "Occupational asthma and rhinitis related to laboratory rats: serum IgG and IgE antibodies to the rat urinary allergen". The Journal of Allergy and Clinical Immunology. 79 (3): 505–15. doi:10.1016/0091-6749(87)90369-1. PMID 3819230.