Enright attended St Edmund Campion Catholic School, Erdington, and later studied Drama at Middlesex University. In 1995, she made her Edinburgh Festival debut as part of the three-hander The West Midland's Serious Comedy Squad. In 2002, she appeared alongside Steve Coogan in episode five, series two of the BBC comedy I'm Alan Partridge as a tax inspector investigating Alan. In 2005, she appeared in the BBC Radio 4 series The Ape that Got Lucky with Chris Addison. In 2006, she appeared in the comedy series Time Trumpet on BBC Two, playing herself as a commentator in the year 2031 looking back on the world nearly thirty years before. From July 2008, she appeared in the BBC comedy series Lab Rats as Cara McIlvenny.
12 October 2008, she played wheelchair user Jackie, a member of the fictional "2 Up, 2 Down", on Peter Kay's Britain's Got the Pop Factor... and Possibly a New Celebrity Jesus Christ Soapstar Superstar Strictly on Ice, a spoof on the talent show genre of programmes. In 2009 she began playing "Carol" in the fifth and sixth series of the BBC Three sitcom Ideal. In 2011, she appeared in Ricky Gervais's and Stephen Merchant's television comedy series Life's Too Short as Sue, Warwick Davis's estranged wife. In 2012, she appeared as baker Sharon in the Sky1 sitcom Trollied. Since April 2013, Enright has appeared as officious job centre worker Angela Bromford in the ITV2 comedy series The Job Lot.
- The Job Lot (2013-2015) as Angela
- Trollied (2012) as Sharon the Baker
- Life's Too Short (2011-2013) as Sue
- Ideal (2009-2011) as Carol
- Lab Rats (2008) as Cara McIlvenny
- Britain's Got the Pop Factor... and Possibly a New Celebrity Jesus Christ Soapstar Superstar Strictly on Ice (2008) as Jackie from contestants "2 Up 2 Down"
- Time Trumpet (2006) as herself (in an imagined future)
- Round (2003) as Ann
- I'm Alan Partridge - I Know What Alan Did Last Summer (2002) as Tax Inspector Catherine
- World of Pub - Ladies (2001)
- Phoenix Nights (aka Peter Kay's Phoenix Nights) - Episode #1.4 (2001) as Beverly Hillscoptu
- That Peter Kay Thing - The Arena (1999)
- I Love a 1970's Christmas (2000) as herself
- Barking (1998), Channel 4 sketch show, as writer and performer
- "Interview: Jo enright, comedian". The Scotsman. 6 January 2011. Retrieved 14 October 2015.
- "The Comedy Agency: Jo Enright". www.thecomedyagency.co.uk. Retrieved 14 October 2015.
- Laws, Roz (3 May 2013). "Birmingham sitcom star Jo Enright goes back to her past for new show". The Birmingham Post. Retrieved 14 October 2015.
- "Qvoice Artistes Search". QVOICE LTD. Archived from the original on 11 March 2007. Retrieved 10 July 2015.