JZ-IV-10 is a piperidine derivative related to cocaine which acts as a highly potent serotonin–norepinephrine–dopamine reuptake inhibitor (also called SNDRI, or triple reuptake inhibitor).[1] The eugeroic modafinil was used as a lead to fuel this compound's discovery.[2][3]

CAS Number
PubChem CID
Chemical and physical data
Molar mass354.937 g/mol g·mol−1
3D model (JSmol)
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See also


  1. WO 2005041875
  2. Zhou, J.; He, R.; Johnson, K. M.; Ye, Y.; Kozikowski, A. P. (2004). "Piperidine-Based Nocaine/Modafinil Hybrid Ligands as Highly Potent Monoamine Transporter Inhibitors: Efficient Drug Discovery by Rational Lead Hybridization". Journal of Medicinal Chemistry. 47 (24): 5821–5824. doi:10.1021/jm040117o. PMC 1395211. PMID 15537337.
  3. He, R.; Kurome, T.; Giberson, K. M.; Johnson, K. M.; Kozikowski, A. P. (2005). "Further Structure-Activity Relationship Studies of Piperidine-Based Monoamine Transporter Inhibitors: Effects of Piperidine Ring Stereochemistry on Potency. Identification of Norepinephrine Transporter Selective Ligands and Broad-Spectrum Transporter Inhibitors". Journal of Medicinal Chemistry. 48 (25): 7970–7979. doi:10.1021/jm050694s. PMID 16335921.

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