Hypoproteinemia is a condition where there is an abnormally low level of protein in the blood. There are several causes that all result in oedema once serum protein levels fall below a certain threshold.[1]

Edema in Hypoproteinemia


  1. Nutritional hypoproteinemia is due to severe limitation of protein intake in the diet. An example of nutritional hypoproteinemia is Kwashiorkor, a type of protein energy malnutrition affecting young children.
  2. Malabsorption
  3. Liver disease can also cause hypoproteinemia by decreasing synthesis of plasma proteins like albumin.
  4. Renal disease like nephrotic syndrome can also result in hypoproteinemia because plasma proteins are lost in the urine.
  5. Sepsis (whole body infection) – macrophages activated in the liver and spleen secrete TNF-alpha into the bloodstream resulting in hypoproteinemia.


Decreased serum protein reduces the osmotic pressure of the blood, leading to loss of fluid from the intravascular compartment, or the blood vessels, to the interstitial tissues, resulting in edema. This is termed as hypoproteinemia.


Hypoproteinemia is often confirmed by testing for serum albumin and total protein levels.[2]


  1. Semrad, Carol E. (2012). "Approach to the Patient with Diarrhea and Malabsorption". Goldman's Cecil Medicine. pp. 895–913. doi:10.1016/b978-1-4377-1604-7.00142-1. ISBN 9781437716047.
  2. Laster, Leonard (1964-02-22). "Protein-losing Gastroenteropathy". JAMA. 187 (8): 227. doi:10.1001/jama.1964.03060210072030. ISSN 0098-7484. PMC 2482745.

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