General Leibniz rule
In calculus, the general Leibniz rule,[1] named after Gottfried Wilhelm Leibniz, generalizes the product rule (which is also known as "Leibniz's rule"). It states that if and are times differentiable functions, then the product is also times differentiable and its th derivative is given by
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Specialized 

where is the binomial coefficient and
This can be proved by using the product rule and mathematical induction.
Second derivative
If, for example, n = 2, the rule gives an expression for the second derivative of a product of two functions:
More than two factors
The formula can be generalized to the product of m differentiable functions f_{1},...,f_{m}.
where the sum extends over all mtuples (k_{1},...,k_{m}) of nonnegative integers with and
are the multinomial coefficients. This is akin to the multinomial formula from algebra.
Proof
The proof of the general Leibniz rule proceeds by induction. Let and be times differentiable functions. The base case when claims that:
which is the usual product rule and is known to be true. Next, assume that the statement holds for a fixed that is, that
Then,
And so the statement holds for and the proof is complete.
Multivariable calculus
With the multiindex notation for partial derivatives of functions of several variables, the Leibniz rule states more generally:
This formula can be used to derive a formula that computes the symbol of the composition of differential operators. In fact, let P and Q be differential operators (with coefficients that are differentiable sufficiently many times) and Since R is also a differential operator, the symbol of R is given by:
A direct computation now gives:
This formula is usually known as the Leibniz formula. It is used to define the composition in the space of symbols, thereby inducing the ring structure.
See also
References
 Olver, Peter J. (2000). Applications of Lie Groups to Differential Equations. Springer. pp. 318–319.