GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.
3D model (JSmol)
|Molar mass||468.564 g·mol−1|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate. It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.
- Pileblad E, and Engberg G. (Dec 1986). "GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies". Naunyn Schmiedebergs Arch Pharmacol. 334 (4): 383–7. PMID 2950328.
- Moy LY; et al. (Feb 2007). "Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter". J Pharmacol Exp Ther. 320 (2): 747–56. doi:10.1124/jpet.106.110791. PMID 17090704.
(no additional rings)
(piperazine attached via side chain)