Frontal release sign

Frontal release signs are primitive reflexes traditionally held to be a sign of disorders that affect the frontal lobes. The appearance of such signs reflects the area of brain dysfunction rather than a specific disorder which may be diffuse such as a dementia, or localised such as a tumor.[1]

Frontal release sign
Differential diagnosisDementia

The only reflex thought to have good localizing value is the palmar grasp reflex which usually signifies damage to the frontal lobe of the opposite side.[1] The glabellar reflex or "glabellar tap" is also present in individuals with extrapyramidal disorders such as Parkinson's disease.[2]

Conceptually, these reflexes are "hard-wired" before birth and are therefore able to be elicited in the newborn. As the brain matures, certain areas (usually within the frontal lobes) exert an inhibitory effect thus causing the reflex to disappear. When disease processes disrupt these inhibitory pathways the reflex is "released" from inhibition and elicitable once again, hence the term "frontal release sign".[3]

Some frontal release signs and their role in infancy:


  1. Walker, H. Kenneth (1990-01-01). Walker, H. Kenneth; Hall, W. Dallas; Hurst, J. Willis (eds.). Clinical Methods: The History, Physical, and Laboratory Examinations (3rd ed.). Boston: Butterworths. ISBN 978-0409900774. PMID 21250236.
  2. Vreeling, Fred W; Verhey, Frans R J; Houx, Peter J; Jolles, Jellemer (1993). "Primitive reflexes in Parkinson's disease". Journal of Neurology, Neurosurgery, and Psychiatry. 56 (12): 1323–1326. doi:10.1136/jnnp.56.12.1323. PMC 1015384. PMID 8270937.
  3. Salloway, Stephen P. (2011-01-01). "Glabellar Reflex". In Kreutzer, Jeffrey S.; DeLuca, John; Caplan, Bruce (eds.). Encyclopedia of Clinical Neuropsychology. Springer New York. p. 1149. doi:10.1007/978-0-387-79948-3_1897. ISBN 9780387799476.
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