Signorelli was a founding member of the Original Memphis Five in 1917, then joined the Original Dixieland Jazz Band briefly in 1921. In 1927 he played in Adrian Rollini's New York ensemble, and subsequently worked with Eddie Lang, Bix Beiderbecke, Matty Malneck and Paul Whiteman. In 1935 he was part of Dick Stabile's All-America "Swing" Band.
As a songwriter, Signorelli composed I'll Never Be The Same (initially called Little Buttercup by Joe Venuti's Blue Four), Gypsy, recorded by Paul Whiteman and his Orchestra, Caprice Futuristic, Evening, Anything, Bass Ale Blues, Great White Way Blues, Park Avenue Fantasy, Sioux City Sue (1924), Shufflin' Mose, Stairway to the Stars, and A Blues Serenade, recorded by Signorelli in 1926, Glenn Miller and his Orchestra in 1935 and Duke Ellington's version in 1938.
- Yanow, Scott (2001). Classic Jazz: Third Ear - the Essential Listening Companion. Hal Leonard Corporation. p. 208. ISBN 9781617744860. Retrieved 20 April 2017.
- Laffler, William D. (July 17, 1957). "Record Review". California, Redlands. Redlands Daily Facts. p. 2. Retrieved November 29, 2015 – via Newspapers.com.
- "(Lakewood ad)". The Plain Speaker. April 15, 1936. p. 18. Retrieved October 13, 2015 – via Newspapers.com.
- Little, Paul (June 27, 1957). "Needle in the Groove". Illinois, Arlington Heights. Arlington Heights Herald. p. 36. Retrieved November 29, 2015 – via Newspapers.com.