Flufenamic acid (FFA) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs:718 Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins. FFA is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6.
|AHFS/Drugs.com||International Drug Names|
|Elimination half-life||~3 h|
|Excretion||50% urine, 36% feces|
|CompTox Dashboard (EPA)|
|ECHA InfoCard||100.007.723 |
|Chemical and physical data|
|Molar mass||281.22991 g/mol g·mol−1|
|3D model (JSmol)|
|Melting point||124 to 125 °C (255 to 257 °F) resolidification and remelting at 134°C to 136°C|
|Solubility in water||Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C)|
It is not widely used in humans as it has a high rate (30-60%) of gastrointestinal side effects.:310 It is generally not available in the US. It is available in some Asian and European countries as a generic.
- Whitehouse M. Drugs to Treat Inflammation: A Historical Overview. pp 707-729 in Frontiers in Medicinal Chemistry, Volume 4. Eds Rahman A, et al. Bentham Science Publishers, 2009 ISBN 9781608052073
- NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
- "Chemical–Gene Interaction Query: Flufenamic Acid (Homo sapiens)". Comparative Toxicogenomics Database. North Carolina State University. Retrieved 4 July 2015.
- Jeffrey K. Aronson. Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs. Elsevier, 2009 ISBN 9780080932941
- Drugs.com Drugs.com international listings for flufenamic acid Page accessed July 3, 2015
|Pyrazolones / |
|Acetic acid derivatives|
and related substances
|Propionic acid derivatives|