Fenproporex (Perphoxene) is a stimulant drug of the phenethylamine and amphetamine chemical classes that was developed in the 1960s. It is used as an appetite suppressant for the treatment of obesity.[2]

Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
ATC code
  • none
Legal status
Legal status
Pharmacokinetic data
Metabolismpartly converted to amphetamine (30 to 60%)[1]
Excretionurine, mainly as amphetamine, about 5 to 9% unchanged[1]
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.036.752
Chemical and physical data
Molar mass188.269 g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

Fenproporex produces amphetamine as a metabolite[3][4] and was withdrawn in many countries following problems with abuse,[5] but it is still prescribed in some countries. It is sometimes combined with benzodiazepines, antidepressants, and other compounds to create a version of the "rainbow diet pill".[6][7][8]

Fenproporex has never been approved by the US Food and Drug Administration (FDA) for sale in the US due to lack of efficacy and safety data. However, in March 2009, the FDA warned consumers that it has been detected as an unlabeled component of diet pills available over the Internet.[9] Fenproporex is designated a Schedule IV controlled substance in the US pursuant to the Controlled Substances Act.[10]

Fenproporex is on the list of substances banned by the World Anti-Doping Agency, and any sportsperson testing positive for the substance faces a ban from competition.[11]


  1. Seyffart, G. (1991). Drug dosage in renal insufficiency. Springer. pp. 245–246. ISBN 978-0-7923-0964-2.
  2. Warembourg H, Jaillard J. Clinical experimentation with fenproporex in the treatment of obesity. Apropos of 40 cases. (French). Journal de la Faculte de médecine et de pharmacie de l'Universite de Lille. 1968 Mar;13(3):Suppl:273-6.
  3. Tognoni, G.; Morselli, P.L.; Garattini, S. (1972). "Amphetamine concentrations in rat brain and human urine after fenproporex administration". European Journal of Pharmacology. 20: 125–126. doi:10.1016/0014-2999(72)90227-0.
  4. Cody, J. D. (1993). "Metabolic Precursors to Amphetamine and Methamphetamine". Forensic Science Review. 5 (2): 109–27. PMID 26270078.
  5. Pelissier-Alicot, Anne-Laure; Piercecchi-Marti, Marie-Dominique; Bartoli, Christophe; Kuhlmann, Erika; Coiffait, Philippe-Emmanuel; Sanvoisin, Alain; Giocanti, Dominique; Leonetti, Georges (2006). "Abusive Prescription of Psychostimulants: A Study of Two Cases". Journal of Forensic Sciences. 51 (2): 407–410. doi:10.1111/j.1556-4029.2006.00078.x. PMID 16566781.
  6. Cohen, Pieter A. (2009). "Imported Fenproporex-based Diet Pills from Brazil: A Report of Two Cases". Journal of General Internal Medicine. 24 (3): 430–433. doi:10.1007/s11606-008-0878-4. PMC 2642570. PMID 19096898.
  7. Cohen, Pieter A.; McCormick, Danny; Casey, Carolyn; Dawson, Glen F.; Hacker, Karen A. (2009). "Imported Compounded Diet Pill Use Among Brazilian Women Immigrants in the United States". Journal of Immigrant and Minority Health. 11 (3): 229–236. doi:10.1007/s10903-007-9099-x. PMID 18066718.
  8. Cohen, Pieter A.; Goday, Alberto; Swann, John P. (September 2012). "The Return of Rainbow Diet Pills". American Journal of Public Health. 102 (9): 1676–1686. doi:10.2105/AJPH.2012.300655. PMC 3482033. PMID 22813089.
  9. https://www.fda.gov/cder/consumerinfo/weight_loss_products.htm
  10. "21 CFR 1308.14(e)(4)". U.S. Government Printing Office. Archived from the original on 2011-10-16. Retrieved 2011-04-20.
  11. The 2009 Prohibited List International Standard Archived February 3, 2009, at the Wayback Machine. World Anti-Doping Agency (2009). Retrieved on 2009-08-18.
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