Ethabuka Reserve is a 213,300–hectare nature reserve in Central West Queensland, Australia, 157 km north-west of Bedourie, 336 km south-west of Boulia and 639 km south of Mount Isa. It lies at the northern end of the Simpson Desert with its western boundary bordering the Northern Territory. It is owned and managed by Bush Heritage Australia (BHA), by which it was purchased in 2004.
Ethabuka is characterised by dunefields and the associated swales, with clay and gibber floodplains. It contains the nationally significant Pulchera waterhole, a semi-permanent wetland fed by the ephemeral Mulligan River. Vegetation communities include gidgee woodlands.
Ethabuka is rich in desert wildlife. Mammals recorded on the property include the mulgara, Forrest's mouse, spinifex hopping mouse, brown desert mouse and sandy inland mouse. Reptiles include the woma python. Threatened bird species recorded are the Australian bustard, yellow chat, painted honeyeater and chestnut quail-thrush. The reserve is part of the Simpson Desert Important Bird Area (IBA), identified as such by BirdLife International for its importance in conserving suitable habitat for Eyrean grasswrens.