Dihydropyridine

Dihydropyridine (DHP) is a molecule based upon pyridine, and the parent of a class of molecules that have been semi-saturated with two substituents replacing one double bond. They are particularly well known in pharmacology as L-type calcium channel blockers, used in the treatment of hypertension. Compared with certain other L-type calcium channel blockers (for example those of the phenylalkylamine class such as verapamil) that have significant action at the heart, they are relatively vascular selective in their mechanism of action in lowering blood pressure.

Dihydropyridine
Names
Systematic IUPAC name
1,4-Dihydropyridine[1]
Identifiers
3D model (JSmol)
ChemSpider
MeSH 1,4-dihydropyridine
Properties
C
5
H
7
N
Molar mass 81.1158 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Class members

Dihydropyridine class L-type calcium channel blockers include, in alphabetical order (brand names vary in different countries):

NameImageBrand name
AmlodipineNorvasc, Istin, Normodipine, Tenox, Cordi Cor
AranidipineSapresta (サプレスタ)
AzelnidipineCalBlock (カルブロック)
BarnidipineVasexten, Libradin, Cyress, HypoCa
BenidipineConiel
CilnidipineAtelec (アテレック), Cilacar, Cinalong, Siscard
ClevidipineCleviprex
Cronidipine
Darodipine
Dexniguldipine
EfonidipineLandel (ランデル)
Elgodipine
Elnadipine
FelodipineRenedil, Plendil
Flordipine
Furnidipine
Iganidipine
IsradipineDynaCirc CR
LacidipineLacipil, Motens, Sakure
Lemildipine
LercanidipineZanidip, Zanidip-Recordati
LevamlodipineEsCordi Cor
Levniguldipine
ManidipineManyper, Caslot, Madipine
NicardipineCardene, Cardene SR
NifedipineAdalat, Nifedical, Procardia, Corinfar, Cordaflex
Niguldipine
Niludipine
NilvadipineNivadil
NimodipineNimotop
NisoldipineSular, Baymycard, Syscor
NitrendipineBaypress, Cardif, Nitrepin, Baylotensin
Olradipine
Oxodipine
Palonidipine
PranidipineAcalas
Ryodipine
Sagandipine
Sornidipine
Teludipine
Tiamdipine
Trombodipine
Vatanidipine

The pharmaceutical drug finerenone is also a dihydrophyridine derivative, but does not act as a calcium channel blocker but as an antimineralocorticoid.

See also

References

  1. "1,4-dihydropyridine - Compound Summary". Pubchem Compound. USA: National Center for Biotechnology Information. 27 March 2005. Identification and Related Records. Retrieved 1 November 2011.
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