Didecyldimethylammonium chloride (DDAC) is an antiseptic/disinfectant that is used in many biocidal applications. They cause disruption of intermolecular interactions and dissociation of lipid bilayers. They are broad spectrum bactericidal and fungicidal and can be used as disinfectant cleaner for linen, recommended for use in hospitals, hotels and industries. It is also used in gynaecology, surgery, ophthalmology, pediatrics, OT, and for the sterilization of surgical instruments, endoscopes and surface disinfection.
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||362.08 g/mol|
|Density||0.87 g/cm3 (20 °C)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
In mice this disinfectant was found to cause infertility and birth defects, and more recently in humans. These studies contradict the older toxicology data set on quaternary ammonia compounds which was reviewed by the U.S. Environmental Protection Agency (U.S. EPA) and the EU Commission.
- Dimethyldioctadecylammonium chloride – longer di-C18 analogue
- "Didecyl dimethyl ammonium chloride", Household Products Database, US Department of Health and Human Services, 2016
- Record of didecyldimethylammonium chloride in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 2 November 2007.
- Brendan Maher (2008). "Lab disinfectant harms mouse fertility". Nature. 453 (7198): 964. doi:10.1038/453964a. PMID 18563110.
- Melin, Vanessa (2014). "Exposure to common quaternary ammonium disinfectants decreases fertility in mice". Reproductive Toxicology (Elmsford, N.Y.). NIH. 50: 163–170. doi:10.1016/j.reprotox.2014.07.071. PMC 4260154. PMID 25483128.
- Gaskins, Audrey (2017). "Occupational use of high-level disinfectants and fecundity among nurses". Scand J Work Environ Health. 43 (2): 171–180. doi:10.5271/sjweh.3623. PMC 5840865. PMID 28125764.
- Office of Prevention, Pesticides and Toxic Substances, US EPA (August 2006). "Reregistration Eligibility Decision for Aliphatic Alkyl Quaternaries (DDAC)". Epa739-R-06-008.CS1 maint: multiple names: authors list (link)