Didecyldimethylammonium chloride

Didecyldimethylammonium chloride (DDAC) is an antiseptic/disinfectant that is used in many biocidal applications. They cause disruption of intermolecular interactions and dissociation of lipid bilayers. They are broad spectrum bactericidal and fungicidal and can be used as disinfectant cleaner for linen, recommended for use in hospitals, hotels and industries. It is also used in gynaecology, surgery, ophthalmology, pediatrics, OT, and for the sterilization of surgical instruments, endoscopes and surface disinfection.

Didecyldimethylammonium chloride
Names
IUPAC name
didecyl-dimethylammonium chloride
Other names
  • DDAC
  • Dimethyldidecylammonium chloride[1]
  • 1-Decanaminium[1]
  • N-decyl-N,N-dimethyl-, chloride[1]
  • Didecyldimethylammonium chloride[1]
  • Didecyl dimethyl ammonium chloride[1]
  • Quaternium-12[1]

Ammonium, didecyldimethyl-, chloride[1]

Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.027.751
UNII
Properties
C22H48ClN
Molar mass 362.08 g/mol
Appearance liquid[2]
Density 0.87 g/cm3 (20 °C)[2]
Pharmacology
D08AJ06 (WHO)
Hazards
Main hazards corrosive[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

In mice this disinfectant was found to cause infertility and birth defects,[3] [4] and more recently in humans.[5] These studies contradict the older toxicology data set on quaternary ammonia compounds which was reviewed by the U.S. Environmental Protection Agency (U.S. EPA) and the EU Commission.[6]

See also

References

  1. "Didecyl dimethyl ammonium chloride", Household Products Database, US Department of Health and Human Services, 2016
  2. Record of didecyldimethylammonium chloride in the GESTIS Substance Database of the Institute for Occupational Safety and Health, accessed on 2 November 2007.
  3. Brendan Maher (2008). "Lab disinfectant harms mouse fertility". Nature. 453 (7198): 964. doi:10.1038/453964a. PMID 18563110.
  4. Melin, Vanessa (2014). "Exposure to common quaternary ammonium disinfectants decreases fertility in mice". Reproductive Toxicology (Elmsford, N.Y.). NIH. 50: 163–170. doi:10.1016/j.reprotox.2014.07.071. PMC 4260154. PMID 25483128.
  5. Gaskins, Audrey (2017). "Occupational use of high-level disinfectants and fecundity among nurses". Scand J Work Environ Health. 43 (2): 171–180. doi:10.5271/sjweh.3623. PMC 5840865. PMID 28125764.
  6. Office of Prevention, Pesticides and Toxic Substances, US EPA (August 2006). "Reregistration Eligibility Decision for Aliphatic Alkyl Quaternaries (DDAC)". Epa739-R-06-008.CS1 maint: multiple names: authors list (link)


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