CFLAR

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.[5][6] Also called c-FLIP (FLICE-like inhibitory protein).

CFLAR
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
External IDsOMIM: 603599 MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q33.1Start201,116,154 bp[1]
End201,176,687 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8837

12633

Ensembl

ENSG00000003402

ENSMUSG00000026031

UniProt

O15519

O35732

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 2: 201.12 – 201.18 MbChr 1: 58.71 – 58.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000003402 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026031 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
  6. Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP" (PDF). Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161.

Further reading

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