Atrioventricular block

Atrioventricular block (AV block) is a type of heart block that occurs when the electrical signal traveling from the atria, or the upper chambers of the heart, to ventricles, or the lower chambers of the heart, is impaired. Normally, the sinoatrial node (SA node) produces an electrical signal to control the heart rate. The signal travels from the SA node to the ventricles through the atrioventricular node (AV node). In an AV block, this electrical signal is either delayed or completely blocked. When the signal is completely blocked, the ventricles produce their own electrical signal to control the heart rate. The heart rate produced by the ventricles is much slower than that produced by the SA node.[1]

Atrioventricular block
SpecialtyCardiology 

Some AV blocks are benign, or normal, in certain people, such as in athletes or children. Other blocks are pathologic, or abnormal, and have several causes, including ischemia, infarction, fibrosis, and drugs.

Anatomy

The synchronized contraction of the heart occurs through a well coordinated electrical signal pathway. The initial electrical signal originates from the SA node located in the upper portion of the right atrium. The electrical signal then travels through both the right and left atrium, and causes the two atria to contract at the same time. This simultaneous contraction results in the P wave seen in an ECG tracing.

The electrical signal then travels to the AV node located on the lower portion of the interatrial septum. At the AV node there is a delay in the electrical signal, which allows the atria to contract and blood to flow from the atria to the ventricles. This delay accounts for the ECG period between the P wave and the QRS complex, and creates the PR interval.

From the AV nodes, the electrical signal travels through Bundle of His and divides into the right bundle and left bundle, which are located within the interventricular septum. Finally, the electrical signal travels into the Purkinje fibers. The division of the signal into a right and left bundle and then into the Purkinje fibers allows for a simultaneous depolarization and contraction of the right and left ventricles. The contraction of the ventricles results in the QRS complex seen on an EKG tracing.

After contraction, the ventricles must depolarize, or reset themselves, in order to allow for a second depolarization and contraction. The depolarization creates the T wave in the ECG tracing.[2][3]

Diagnosis

An electrocardiogram, or ECG, is used to differentiate between the different types of AV block. In AV block, there is a disruption between the signal traveling from the atria to the ventricles. This results in abnormalities in the PR interval, as well as the relationship between P waves and QRS complexes on the ECG tracing.[1][4] If the patient is symptomatic from their suspected AV block, it is important that an ECG is also obtained while having symptoms. Physicians may also order a continuous ECG (i.e. Holter monitor or implanted cardiac monitor) to monitor the patient for symptoms and conduction abnormalities over a longer period of time, as AV blocks can be intermittent.[5]

Because some types of AV block can be associated with underlying structural heart disease, patients may also undergo echocardiogram to look at the heart and assess the function.[5]

Laboratory diagnosis for AV blocks include electrolyte, drug level and cardiac enzyme level tests.[6] Based upon clinical suspicion, the physician may do lab tests to assess for reversible causes of AV block, such as hypothyroidism, rheumatologic disorders, and infections (such as Lyme disease).[5]

Classification

There are three types, or degrees, of AV block: (1) first-degree, (2) second-degree, and (3) third-degree, with third-degree being the most severe. An ECG is used to differentiate between the different types of AV block.

First-degree Atrioventricular Block

First-degree AV block occurs when there is a delay, but not disruption, as the electrical signal moves between the atrium and the ventricles through the AV node.[7] On ECG, this is defined by a PR interval greater than 200 msec. Additionally, there are no dropped, or skipped, beats.[1][4]

Second-degree Atrioventricular Block

Second-degree AV block occurs when the electrical signal between the atria and ventricles is even more impaired than in a first-degree AV block. In a second-degree AV block, the impairment results in a failure to conduct an impulse, which causes a skipped beat. [8]

Mobitz I

Mobitz I is characterized by a progressive, yet, reversible block of the AV node. On ECG, this is defined by a progressive prolongation of the PR interval, with a resulting dropped beat (the PR interval gets longer and longer until a beat is finally dropped, or skipped).[4][8]

Some patients are asymptomatic; those who have symptoms respond to treatment effectively. There is low risk of a Mobitz I AV block leading to heart attack and complete heart block.[8]

Mobitz II

Mobitz II is caused by a sudden, unexpected failure of the His-Purkinje cells to conduct the electrical impulse. On ECG, the PR interval is unchanged from beat to beat, but there is a sudden failure to conduct the signal to the ventricles, and a resulting random skipped beat.[4]

The risks and possible effects of Mobitz II are much more severe than Mobitz I in that it can lead to severe heart attack.[8][9]

Third-degree Atrioventricular Block

Third-degree AV block occurs when the signal between the atria and ventricles is completely blocked, and there is no communication between the two. None of the signals from the upper chambers make it to the lower chambers. On ECG, there is no relationship between P waves and QRS complexes, meaning the P waves and QRS complexes are not in a 1:1 ratio.

Third-degree AV block is the most severe of the AV blocks. Persons suffering third-degree AV block need emergency treatment including but not limited to a pacemaker.[10]


Etiology

There are many causes of AV block, ranging from a normal variant among people to the result of a heart attack.

First-degree AV block and Mobitz I second-degree block are often thought to be just normal, benign, conditions in patients, and do not often result from a severe underlying condition.[1]

Mobitz II second-degree block and third-degree AV block are not normal variants, and are associated with an underlying condition. Common causes include ischemia (lack of blood flow and oxygen to the heart muscle) or progressive fibrosis (excessive scaring) of the heart. It is also possible that high degree block can result after cardiac surgery during which the surgeon was in close proximity to the electrical conduction system and accidentally injured it. Reversible causes of Mobitz II and third-degree heart block include untreated Lyme disease, hypothyroidism, hyperkalemia (high levels of potassium), and drug toxicity. Drugs that slow the conduction of the electrical signal through AV node, such as beta-blockers, digoxin, calcium channel blockers, and amiodarone, can cause heart block if they are taken in excessive amounts, or the levels in the blood get too high.[1][8][10]

Management

Management is dependent upon the severity, or degree, of the blockage, the consistency of symptoms, as well as the cause of the AV block.

Patients with first-degree AV block do not have any resulting severe or life-threatening symptoms, such as symptomatic bradycardia or hypotension, and, thus, do not require treatment.[1]

Similarly, patients with second-degree Mobitz I AV block rarely develop life-threatening symptoms, and patients who are asymptomatic do not require treatment. However, in some cases, patients with Mobtz I block can develop life-threatening symptoms that requires intervention. These patients often respond well to atropine, but make require temporary transcutaneous pacing or transvenous pacing until they are not longer symptomatic.[8]

Patients with second-degree Mobitz II and third-degree heart block are much more likely to have symptomatic bradycardia and hemodynamic instability, such as hypotension. Additionally, there is an increased risk of patients with Mobitz II heart block developing third-degree heart block. Therefore, these patients often require temporary pacing with transcutaneous or transvenous pacing wires, and many will ultimately require a permanent implanted pacemaker.[5][8][10]

If the heart block is found to be caused by a reversible condition, such as Lyme disease, the underlying condition should first be treated. Often times, this will lead to resolution of the heart block and the associated symptoms.[5]

References

  1. Kashou, Anthony H.; Goyal, Amandeep; Nguyen, Tran; Chhabra, Lovely (2019), "Atrioventricular Block", StatPearls, StatPearls Publishing, PMID 29083636, retrieved 2019-11-12
  2. Lilly, Leonard (2006). Pathophysiology of Heart Disease. Lippincott Williams & Wilkins. ISBN 978-0-7817-6321-9.
  3. Klabunde, Richard E. (2012). Cardiovascular physiology concepts (2nd ed.). Philadelphia, PA: Lippincott Williams & Wilkins/Wolters Kluwer. ISBN 9781451113846. OCLC 712765593.
  4. Dubin, Dale, 1940- (2000). Rapid interpretation of EKG's : an interactive course (6th ed ed.). Tampa, Fla.: Cover Pub. Co. ISBN 9780912912066. OCLC 45498043.CS1 maint: multiple names: authors list (link) CS1 maint: extra text (link)
  5. Kusumoto, Fred M.; Schoenfeld, Mark H.; Barrett, Coletta; Edgerton, James R.; Ellenbogen, Kenneth A.; Gold, Michael R.; Goldschlager, Nora F.; Hamilton, Robert M.; Joglar, José A.; Kim, Robert J.; Lee, Richard (2019-08-20). "2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society". Circulation. 140 (8): e382–e482. doi:10.1161/CIR.0000000000000628. ISSN 1524-4539. PMID 30586772.
  6. "Atrioventricular Block: Practice Essentials, Background, Pathophysiology". 2017-01-06. Cite journal requires |journal= (help)
  7. "Types of Heart Block - NHLBI, NIH". www.nhlbi.nih.gov. Retrieved 2017-03-22.
  8. Mangi, Muhammad Asif; Jones, Wesley M.; Napier, Laura (2019), "Atrioventricular Block Second-Degree", StatPearls, StatPearls Publishing, PMID 29493981, retrieved 2019-11-12
  9. Wogan, J. M.; Lowenstein, S. R.; Gordon, G. S. (1993-01-01). "Second-degree atrioventricular block: Mobitz type II". The Journal of Emergency Medicine. 11 (1): 47–54. doi:10.1016/0736-4679(93)90009-v. ISSN 0736-4679. PMID 8445186.
  10. Knabben, Vinicius; Chhabra, Lovely; Slane, Matthew (2019), "Third-Degree Atrioventricular Block", StatPearls, StatPearls Publishing, PMID 31424783, retrieved 2019-11-12
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External resources
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