Apyu is a former Karok settlement in Humboldt County, California. It was located about 1 mile (1.6 km) above the Salmon River mouth near the upper rapids above the mouth of the Salmon across from Ishipishi. Its precise location is unknown. It was approximately 0.5 miles (0.80 km) east of Somes Bar, a community in Siskiyou County.
- U.S. Geological Survey Geographic Names Information System: Apyu, California
- Alfred Louis Kroeber (1925). Handbook of the Indians of California. Courier Dover Publications. pp. 973–. ISBN 978-0-486-23368-0.