The borough was formed in 1998 by merging the former boroughs of Amsterdam-Zuid and De Pijp, lying southwest and south of the centre of Amsterdam. In 2010 the borough was merged with Zuideramstel to form the borough Amsterdam-Zuid. On 1 January 2005 the borough had a population of 83,696. It included some of the richest neighbourhoods of Amsterdam, mostly developed at the end of the 19th century.
The following neighbourhoods were included in the borough Oud-Zuid:
From the former borough of De Pijp:
From the former borough Amsterdam-Zuid (as it existed from 1990 to 1998):
- Museum Quarter
- Vondelpark (park)
Before 1990 in popular usage amongst Amsterdammers, "Oud-Zuid" referred to a much smaller area: the Museumkwartier (incl. Duivelseiland) and the Willemspark area. The City of Amsterdam used the term "Oud-Zuid" to refer to a larger area which also included De Pijp and the Schinkelbuurt.
Popular tourist and cultural destinations are located in the borough of Oud-Zuid, including:
- the Albert Cuyp Market, which is held on the Albert Cuypstraat
- the Vondelpark: a 47 ha (120 acres) park containing an open-air theatre and until April 4, 2012 the museum of the EYE Film Institute
- the Stedelijk Museum and Van Gogh Museum, as well as the Rijksmuseum Amsterdam are located on the Museumplein ('Museum Square')
- the Heineken Experience located in the former Heineken brewery
- the Concertgebouw, a concert hall located on the Museumplein