ATP5C1

The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.[5][6][7]

ATP5F1C
Identifiers
AliasesATP5F1C, ATP5C, ATP5CL1, ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1, ATP5C1, ATP synthase F1 subunit gamma
External IDsOMIM: 108729 MGI: 1261437 HomoloGene: 3792 GeneCards: ATP5F1C
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p14Start7,788,147 bp[1]
End7,807,815 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

509

11949

Ensembl

ENSG00000165629

ENSMUSG00000025781

UniProt

P36542

Q91VR2

RefSeq (mRNA)

NM_001001973
NM_005174
NM_001320886

NM_001112738
NM_020615

RefSeq (protein)

NP_001001973
NP_001307815
NP_005165

NP_001106209
NP_065640

Location (UCSC)Chr 10: 7.79 – 7.81 MbChr 2: 10.06 – 10.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes adenosine triphosphate (ATP) synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, F0, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000165629 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025781 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet. 93 (5): 600–2. doi:10.1007/bf00202832. PMID 8168843.
  6. Matsuda C, Endo H, Ohta S, Kagawa Y (Dec 1993). "Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing". J Biol Chem. 268 (33): 24950–8. PMID 8227057.
  7. "Entrez Gene: ATP5F1C ATP synthase F1 subunit gamma".

Further reading


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