ATP1A4

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.[5][6][7]

ATP1A4
Identifiers
AliasesATP1A4, ATP1A1, ATP1AL2, ATPase Na+/K+ transporting subunit alpha 4
External IDsOMIM: 607321 MGI: 1351335 HomoloGene: 113769 GeneCards: ATP1A4
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.2Start160,151,570 bp[1]
End160,186,977 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

480

27222

Ensembl

ENSG00000132681

ENSMUSG00000007107

UniProt

Q13733

Q9WV27

RefSeq (mRNA)

NM_001001734
NM_144699

NM_013734

RefSeq (protein)

NP_001001734
NP_653300

NP_038762

Location (UCSC)Chr 1: 160.15 – 160.19 MbChr 1: 172.22 – 172.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000132681 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000007107 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Buetow KH, Nishimura D, Nakamura Y, Jiang O, Murray JC (May 1991). "A detailed multipoint gene map of chromosome 1q". Genomics. 8 (1): 13–21. doi:10.1016/0888-7543(90)90220-O. PMID 1981991.
  6. Shull MM, Lingrel JB (Jul 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc Natl Acad Sci U S A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
  7. "Entrez Gene: ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide".

Further reading


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