Uesugi Tsunakatsu (上杉綱勝, 25 January 1639 – 30 June 1664) was the third head of Yonezawa Domain from the Uesugi clan. In 1645, he became the third head of Yonezawa Domain. In 1654, he married Haruhime, daughter of Hoshina Masayuki. They adopted a son of Tsunakatsu's younger sister with Kira Yoshinaka, Uesugi Tsunanori. Later his wife died because she was poisoned by her mother. After his wife died, he had a concubine who died at a young age, Ofu no Kata.