Karl Deisseroth

Karl Alexander Deisseroth (born 18 November 1971) is the D. H. Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences at Stanford University. He earned his AB in biochemical sciences from Harvard University and his MD/PhD in neuroscience from Stanford University in 1998, and completed medical internship and psychiatry residency at Stanford Medical School. He is known for creating and developing the technologies of CLARITY and optogenetics, and for applying integrated optical and genetic strategies to study normal neural circuit function as well as dysfunction in neurological and psychiatric disease. He has led his laboratory at Stanford University since 2004, serves as an attending physician at Stanford Hospital and Clinics, and has been affiliated with the Howard Hughes Medical Institute (HHMI) since 2009.[1][2] Since 2014 he is a foreign Adjunct Professor at Sweden's prestigious Karolinska medical institute.

Karl Deisseroth
Born (1971-11-18) November 18, 1971
Alma materHarvard University, Stanford University
Known forOptogenetics, CLARITY
Spouse(s)Michelle Monje
AwardsGolden Brain Award (2009)
Richard Lounsbery Award (2013)
Dickson Prize in Science (2013)
Keio Medical Science Prize (2014)
Albany Medical Center Prize (2015)
BBVA Foundation Frontiers of Knowledge Award (2015)
Breakthrough Prize in Life Sciences (2016)
Kyoto Prize (2018)
Rumford Prize (2019)
Warren Alpert Foundation Prize 2019
Scientific career
FieldsNeuroscience, Psychiatry, Bioengineering
InstitutionsStanford University, Karolinska Institutet
Academic advisorsRichard Tsien, Robert Malenka
Doctoral studentsFeng Zhang


In 2005 Deisseroth's laboratory, including graduate students Edward Boyden and Feng Zhang, published the first demonstration of the use of microbial opsin genes to achieve optogenetic control of neurons, allowing reliable control of action potentials with light at millisecond precision.[3] Deisseroth named this field "optogenetics" in 2006 and followed up with optogenetic technology development work, leading to many applications including to psychiatry and neurology. In 2010, the journal Nature Methods named optogenetics "Method of the Year".[4] In 2013, Deisseroth was senior author of a paper on a new technology named CLARITY, with first author postdoctoral fellow in his lab Kwanghun Chung, which makes biological tissues such as mammalian brains translucent and accessible to molecular probes.[5][6]

On November 29, 2015, he was awarded the Breakthrough Prize in Life Sciences.[7]

He has received the 2015 BBVA Foundation Frontiers of Knowledge Award in Biomedicine, jointly with Edward Boyden and Gero Miesenböck, for the development of optogenetics, the most precise technique for studying the brain today. He was awarded Japan's highest private award, the Kyoto Prize, in 2018 for "his discovery of optogenetics and development of casual systems neurosciences", becoming the youngest receipt of the award till date[8][9]. In 2019, he was awarded the Rumford Prize for "extraordinary contributions related to the invention and refinement of optogenetics," with Ernst Bamberg, Ed Boyden, Peter Hegemann, Gero Miesenböck, and Georg Nagel.[10] In the same year, he, Boyden, Hegemann, and Miesenböck won the Warren Alpert Foundation Prize.[11]

Deisseroth is a member of the National Academy of Medicine, and the National Academy of Sciences. Deisseroth is also a Brain & Behavior Research Foundation Scientific Council Member and NARSAD Grantee.

Honors and awards


  1. "Karl Deisseroth, MD, PhD". HHMI.org. Retrieved 2016-03-01.
  2. Smith, Kerri (29 May 2013). "Neuroscience: Method man". Nature News. Retrieved 27 February 2014.
  3. Boyden ES; Zhang F; Bamberg E; Nagel G; Deisseroth K. (September 2005). "Millisecond-timescale, genetically targeted optical control of neural activity". Nature Neuroscience. 8 (9): 1263–8. doi:10.1038/nn1525. PMID 16116447.
  4. "Method of the Year 2010". Nature Methods. 8 (1): 1–1. 20 December 2010. doi:10.1038/nmeth.f.321.
  5. Brains as Clear as Jell-O for Scientists to Explore, April 10, 2013 The New York Times
  6. Chung, Kwanghun; Wallace, Jenelle; Kim, Sung-Yon; Kalyanasundaram, Sandhiya; Andalman, Aaron S.; Davidson, Thomas J.; Mirzabekov, Julie J.; Zalocusky, Kelly A.; Mattis, Joanna; Denisin, Aleksandra K.; Pak, Sally; Bernstein, Hannah; Ramakrishnan, Charu; Grosenick, Logan; Gradinaru, Viviana; Deisseroth, Karl (10 April 2013). "Structural and molecular interrogation of intact biological systems". Nature. 497 (7449): 332–337. doi:10.1038/nature12107. PMC 4092167. PMID 23575631.
  7. "Breakthrough Prize". Breakthrough Prize. Retrieved 2016-03-01.
  8. "2018 Kyoto Prize Laureates received their Awards on November 10 | Kyoto Prize USA". Retrieved 2019-06-12.
  9. Scovie, Jay (2018). "Stanford Neuroscientist Karl Deisseroth Receives Japan's Kyoto Prize in Advanced Technology". Business Wire. Retrieved 2019-06-13.
  10. "Rumford Prize Awarded for the Invention and Refinement of Optogenetics". American Academy of Arts & Sciences. Retrieved 2019-03-12.
  11. "2019 Warren Alpert Prize Recipients Announced | Warren Alpert Foundation Prize". warrenalpert.org. Retrieved 2019-07-16.
  12. "White House Announces 2005 Awards for Early Career Scientists and Engineers" (PDF). Office of Science and Technology Policy, Executive Office of the President. 2006-07-26. Retrieved 2018-11-12 via Center for Space Research, University of Texas at Austin.
  13. "34th Annual W. Alden Spencer Award and Lecture". Columbia University. Retrieved 24 August 2012.
  14. http://www.brandeis.edu/rosenstiel/gabbayaward/past.html
  15. "Prize Winners". Lundbeckfonden (in Danish). Retrieved 2019-03-13.
  16. Optogenetics earns Stanford professor Karl Deisseroth the Keio prize in medicine, Stanford, 2014
  17. "Albany Medical College: AlbanyPrize". Amc.edu. 2015-08-14. Retrieved 2016-03-01.
  18. "LURIE PRIZE OVERVIEW". Foundation for the National Institutes of Health. Archived from the original on 1 September 2015. Retrieved 14 August 2015.
  19. Harvey Prize 2016
  20. "Kyoto Prize, Inamori Foundation". Kyoto Prize, Inamori Foundation. Retrieved 2019-03-13.
  21. "2019 Warren Alpert Prize Recipients Announced | Warren Alpert Foundation Prize". warrenalpert.org. Retrieved 2019-07-16.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.