David S. Eisenberg (born 15 March 1939) is an American biochemist and biophysicist best known for his contributions to structural biology and computational molecular biology. A professor at the University of California, Los Angeles since the early 1970s and director of the UCLA-DOE Institute for Genomics & Proteomics since the early 1990s, as well as a member of the California NanoSystems Institute (CNSI) at UCLA.
|Alma mater||Harvard University (undergraduate)|
The Queen's College, Oxford (postgraduate)
|Awards||Harvey Prize (2008)|
ISCB Senior Scientist Award (2013)
|Institutions||Howard Hughes Medical Institute|
University of Oxford
University of California, Los Angeles
California Institute of Technology
|Thesis||Some problems in the electronic structure of molecules (1965)|
|Doctoral advisor||Charles Coulson|
|Doctoral students||Michael Gribskov|
|Other notable students||Charlotte Deane|
Eisenberg attended Harvard University and graduated in 1961 with an A.B. in Biochemical Sciences. He went on to the University of Oxford, where he was awarded a D.Phil in 1965 for research supervised by Charles Coulson.
Eisenberg's current research focuses on the structural biology of amyloidogenic proteins, while his computational efforts largely center on the development of bioinformatic/proteomic methodologies for elucidation and analysis of protein interaction networks. His research group hosts the Database of Interacting Proteins.
- Postdoctoral research, Princeton University (1964–1966; with Walter Kauzmann)
- Postdoctoral research, California Institute of Technology (1966–1969; with Richard E. Dickerson)
- Professor, Department of Chemistry & Biochemistry, UCLA, USA (1969–Present)
- Professor, Department of Biological Chemistry, UCLA Medical School
- Director, UCLA-DOE Institute for Genomics & Proteomics (1993–Present)
- Member, California NanoSystems Institute (CNSI), UCLA
- Investigator, Howard Hughes Medical Institute (2001–Present)
He was the recipient of Harvey Prize (Human Health) 2008 in recognition of his contributions in unfolding the structure of amyloid fibrils. The award was presented to him at a ceremony that took place on March 23, 2009 at the Technion. This recently recognized protein state provides opportunities to understand cells in health and disease.
- L.J. Henderson Prize (1961)
- Harvard College Honorary Scholarships (1958-1960)
- Rhodes Scholarship (1961-1964)
- USPHS Career Development Award (1972-1977)
- UCLA Distinguished Teaching Award (1975)
- McCoy Award of the UCLA Department of Chemistry and Biochemistry for innovative research (1982)
- Member, National Academy of Sciences (1989; Biophysics & Computational Biology section)
- Pierce Award of the Immunotoxin Society (1992)
- Protein Society Stein & Moore Award (1996)
- American Chemical Society Repligen Corporation Award in Chemistry of Biological Processes (1998)
- Investigator, Howard Hughes Medical Institute (2000)
- Amgen Award of the Protein Society (2000)
- Fellow, American Association for the Advancement of Science (2001)
- UCLA's Seaborg Medal (2004)
- Harvard University's Westheimer Medal (2005)
- ACS Nobel Laureate Signature Award for Graduate Education in Chemistry (2008, as preceptor, student was Rebecca Anne Nelson)
- ISCB (International Society for Computational Biology) Senior Scientist Award (2013)
- Fogg, C. N.; Kovats, D. E. (2013). "International Society for Computational Biology Honors David Eisenberg with 2013 Accomplishment by a Senior Scientist Award". PLoS Computational Biology. 9 (6): e1003116. doi:10.1371/journal.pcbi.1003116. PMC 3681620.
- Eisenberg, D.; McLachlan, A. D. (1986). "Solvation energy in protein folding and binding". Nature. 319 (6050): 199–203. doi:10.1038/319199a0. PMID 3945310.
- Balbirnie, M.; Grothe, R.; Eisenberg, D. S. (2001). "An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated beta -sheet structure for amyloid". Proceedings of the National Academy of Sciences. 98 (5): 2375–2380. doi:10.1073/pnas.041617698. PMC 30146. PMID 11226247.
- Lüthy, R.; Bowie, J. U.; Eisenberg, D. (1992). "Assessment of protein models with three-dimensional profiles". Nature. 356 (6364): 83–85. doi:10.1038/356083a0. PMID 1538787.
- Chapman, M. S.; Suh, S. W.; Curmi, P. M.; Cascio, D.; Smith, W. W.; Eisenberg, D. S. (1988). "Tertiary structure of plant RuBisCO: Domains and their contacts". Science. 241 (4861): 71–74. doi:10.1126/science.3133767. PMID 3133767.
- David Eisenberg publications indexed by Google Scholar
- HHMI profile of David Eisenberg
- The Eisenberg research lab at UCLA
- UCLA-DOE Institute for Genomics & Proteomics
- David Eisenberg’s speech during the Harvey Prize ceremony on YouTube
- Eisenberg, David; Kauzmann, Walter (2005). The structure and properties of water. Oxford: Clarendon Press. ISBN 0-19-857026-0.
- List of publications from Microsoft Academic
- David Eisenberg's publications indexed by the Scopus bibliographic database. (subscription required)
- Eisenberg, David J. (1965). Some problems in the electronic structure of molecules (PhD thesis). University of Oxford.
- Salwinski, L.; Miller, C. S.; Smith, A. J.; Pettit, F. K.; Bowie, J. U.; Eisenberg, D. (2004). "The Database of Interacting Proteins: 2004 update". Nucleic Acids Research. 32 (90001): D449–D451. doi:10.1093/nar/gkh086. PMC 308820. PMID 14681454.
- Harvey Prize Award